Reversely immortalized mouse salivary gland cells presented a promising metabolic and fibrotic response upon BMP9/Gdf2 stimulation

Abstract The submandibular gland (SMG) and the sublingual gland (SLG) are two of the three major salivary glands in mammals.In mice, they are adjacent to each other and open into the oral cavity, producing saliva to lubricate the mouth and aid in food digestion.Though salivary gland dysfunction accompanied with fibrosis and metabolic disturbance is

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Poxvirus Interactions with the Host Ubiquitin System

The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions.With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in manipulating protein function.As intracellular parasites viruses have evolved to modulate the cellular e

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Economic burden in the management of transfusion-dependent thalassaemia patients in Malaysia from a societal perspective

Abstract Background Transfusion-dependent thalassaemia (TDT) is a hereditary blood disorder in which blood transfusion is the mainstay treatment to prolong survival and improve quality of life.Patients with this disease require blood transfusion at more than 100 ml/kg annually and iron-chelating therapy (ICT) to prevent iron overload (IOL) complica

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